Results
| PMID | 25446542 |
| Gene Name | MUC16 |
| Condition | Endometriosis (Endometriomas (OMAs), deep infiltrating lesions (DIE), and superficial endometriosis (SUP)) |
| Association |
Associated |
| Population size | 685 |
| Population details | 685 (406 women with histologically proven endometriosis, 279 women without endometriosis.) |
| Sex | Female |
| Other associated phenotypes |
Deep endometriosis |
|
J Minim Invasive Gynecol. 2015 Feb;22(2):275-84. doi: 10.1016/j.jmig.2014.10.013. Santulli, Pietro| Streuli, Isabelle| Melonio, Isabelle| Marcellin, Louis| M'Baye, Magate| Bititi, Amine| Borghese, Bruno| Lafay Pillet, Marie-Christine| Chapron, Charles Department of Gynecology Obstetrics II and Reproductive Medicine, Universite Paris Descartes, Sorbonne Paris Cite, Faculte de Medecine, AP- HP, Hopital Cochin, Paris, France; Laboratoire d'immunologie, Universite Paris Descartes, Sorbonne Paris Cite, F STUDY OBJECTIVE: To determine whether cancer antigen-125 (CA-125) levels are increased in women with endometriosis, especially in those with endometriomas (OMAs), deep infiltrating lesions (DIE), and superficial endometriosis (SUP) compared with controls without endometriosis in a large cohort of operated women. DESIGN: Cross-sectional study (Canadian Task Force classification II-2). SETTING: Tertiary-care university hospital. PATIENTS: Four hundred six women with histologically proven endometriosis and 279 women without endometriosis. INTERVENTIONS: Surgical examination of the abdomino-pelvic cavity. MEASUREMENTS AND MAIN RESULTS: Preoperative serum CA-125 antigen levels were evaluated by electrochemoluminescence immunoassay in women with endometriosis and controls. Correlations between serum CA-125 levels and clinical and anatomical characteristics of disease severity were examined. Women with endometriosis displayed higher mean serum CA-125 levels compared with disease-free controls (50.1 +/- 62.4 U/mL vs 22.5 +/- 25.2 U/mL; p Mesh Terms: Adult| Biomarkers/blood| CA-125 Antigen/*blood| Cross-Sectional Studies| Endometriosis/*blood/*pathology/surgery| Female| France| Humans| Middle Aged| Peritoneum/*pathology| Severity of Illness Index| Young Adult|DA 2015/09/19 06:00 |
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